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Review
. 2003 Jan 24;112(2):147-50.
doi: 10.1016/s0092-8674(03)00037-0.

Sensing stretch is fundamental

Neal D Epstein  1 , Julien S Davis
Affiliations
Free article
Review

Sensing stretch is fundamental

Neal D Epstein et al. Cell. .
Free article

Abstract

Stretch induces changes in cardiomyocyte biology that are implicated in heart failure, but the mechanism by which stretch is sensed and signals are transduced is unknown. New understanding of the Z disc elements of contractile units are beginning to elucidate the mechanism of stretch sensing and its relation to cardiac adaptation and disease.

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