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Review
. 2003 Jan 13;88(1):1-3.
doi: 10.1038/sj.bjc.6600745.

Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma

M Dedicoat  1 , R Newton
Affiliations
Review

Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma

M Dedicoat et al. Br J Cancer. .

Abstract

In the years before human immunodeficiency virus (HIV) infection, the incidence of Kaposi's sarcoma varied markedly across the African continent, and it was a disease primarily affecting men. In contrast, the evidence reviewed here shows that the causal virus-Kaposi's sarcoma associated herpesvirus (KSHV)-is prevalent in many African countries, including places where Kaposi's sarcoma was almost unknown before HIV, and that it is as common in women as in men. Therefore, the geographical distribution of Kaposi's sarcoma in Africa before the spread of HIV and its predominance as a disease affecting men are not a simple reflection of the distribution of KSHV. Since the epidemic of HIV in Africa, Kaposi's sarcoma has become relatively more frequent in women, and the incidence has increased in countries where it was previously rare, but where KSHV is prevalent, as well as in countries where it was already common. These changes point to a role for other (as yet unknown) factors in the aetiology of Kaposi's sarcoma that may have the most effect in the absence of concurrent HIV infection.

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References

    1. Ablashi D, Chatlynne L, Cooper H, Thomas D, Yadav M, Norhanom AW, Chandana AK, Curdboonchart V, Kulpradist SA, Patnaik M, Liegmann K, Masood R, Reitz M, Cleghorn F, Manns A, Levine PH, Rabkin C, Biggar R, Jensen F, Gill P, Jack N, Edwards J, Whitman J, Boshoff C (1999) Sero-prevalence of human herpesvirus 8 (HHV8) in countries of Southeast Asia compared to the USA, Caribbean and Africa. Br J of Cancer 81(5): 893–897 - PMC - PubMed
    1. Andreoni M, El-Sawaf G, Rezza G, Ensoli B, Nicastri E, Ventura L, Ercoli L, Sarmati L, Rocchi G (1999) High seroprevalence of antibodies to human herpesvirus 8 in Egyptian children: evidence of nonsexual transmission. J Natl Cancer Inst 91(5): 465–469 - PubMed
    1. Andreoni M, Sarmati L, Nicastri E, El Sawaf G, El Zalabani M, Uccella I, Bugarini R, Parisi S, Rezza G (2002) Primary human herpesvirus 8 infection in immunocompetent children. J Am Med Assoc 287: 1295–1300 - PubMed
    1. Ariyoshi K, Schim van der Loeff M, Cook P, Whitby D, Corrah T, Jaffar S, Cham F, Sabally S, O'Donovan D, Weiss RA, Schulz TF, Whittle H (1998) Kaposi's sarcoma in the Gambia, West Africa is less frequent in human immunodeficiency virus type 2 than in human immunodeficiency type 1 infection despite a high prevalence of human herpesvirus 8. J Human Virol 1(3): 185–186 - PubMed
    1. Bassett MT, Chokunonga E, Mauchaza B, Levy L, Ferlay J, Parkin DM (1995) Cancer in the African population of Harare, Zimbabwe in 1990–92. Int J Cancer 63: 29–36 - PubMed

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