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. 2003 Jan 13;88(1):47-9.
doi: 10.1038/sj.bjc.6600689.

Delayed infection, late tonsillectomy or adenoidectomy and adult leukaemia: a case-control study

P Vineis  1 , L Miligi, P Crosignani, L Davico, A Fontana, G Masala, O Nanni, V Ramazzotti, S Rodella, E Stagnaro, R Tumino, C Viganò, C Vindigni, A S Costantini
Affiliations

Delayed infection, late tonsillectomy or adenoidectomy and adult leukaemia: a case-control study

P Vineis et al. Br J Cancer. .

Abstract

In a population-based case-control study among adults in Italy, of 261 lymphoid and 313 myeloid leukaemias and 1718 controls, a later age at adenoidectomy and tonsillectomy (after age 10 years) increased considerably the risk of lymphocytic (but not myeloid) leukaemia (odds ratio 4.2, 95% confidence interval 1.1-16.2). We propose that late infection is a proliferative stimulus for B-cells.

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