doi: 10.1093/jnci/56.2.283.
Mutagenicity of metronidazole: presence of several active metabolites in human urine
- PMID: 1255761
- DOI: 10.1093/jnci/56.2.283
Item in Clipboard
Mutagenicity of metronidazole: presence of several active metabolites in human urine
J Natl Cancer Inst.
1976 Feb.
Abstract
Mutagenic activity was found in the urine of 10 patients given therapeutic dosages of metronidazole orally or per vagina. Paper chromatographic separation revealed that mutagenicity in the urine was associated with unmodified metronidazole and at least four of its known urinary metabolites. Activity was also recovered in a region of the chromatogram heretofore not assigned to a metronidazole metabolite.
Similar articles
-
The contribution of metronidazole and two metabolites to the mutagenic activity detected in urine of treated humans and mice.Cancer Res. 1977 Feb;37(2):629-33. Cancer Res. 1977. PMID: 318924
-
Metronidazole bioassay.Antimicrob Agents Chemother. 1976 Feb;9(2):260-1. doi: 10.1128/AAC.9.2.260. Antimicrob Agents Chemother. 1976. PMID: 178274 Free PMC article.
-
Metronidazole: proven benefits and potential risks.Johns Hopkins Med J. 1980 Jul;147(1):1-9. Johns Hopkins Med J. 1980. PMID: 7382255
-
Metronidazole.Aust N Z J Obstet Gynaecol. 1987 Aug;27(3):228-30. doi: 10.1111/j.1479-828x.1987.tb00994.x. Aust N Z J Obstet Gynaecol. 1987. PMID: 3325019 Review. No abstract available.
-
[Metronidazole].Ann Dermatol Venereol. 2001 Sep;128(8-9):903-9. Ann Dermatol Venereol. 2001. PMID: 11590342 Review. French.
Cited by
-
Genotoxicity revaluation of three commercial nitroheterocyclic drugs: nifurtimox, benznidazole, and metronidazole.J Parasitol Res. 2009;2009:463575. doi: 10.1155/2009/463575. Epub 2009 Oct 21. J Parasitol Res. 2009. PMID: 20981287 Free PMC article.
-
Oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole.Br J Cancer. 1978 Sep;38(3):411-7. doi: 10.1038/bjc.1978.222. Br J Cancer. 1978. PMID: 708572 Free PMC article.
-
The effect of therapeutic drugs used in inflammatory bowel disease on the incidence and growth of colonic cancer in the dimethylhydrazine rat model.Br J Cancer. 1992 Nov;66(5):777-80. doi: 10.1038/bjc.1992.359. Br J Cancer. 1992. PMID: 1358165 Free PMC article.
-
The place of the host-mediated assay.Arch Toxicol. 1980 Nov;46(1-2):111-21. doi: 10.1007/BF00361250. Arch Toxicol. 1980. PMID: 7235988 No abstract available.
-
Antitrichomonad action, mutagenicity, and reduction of metronidazole and other nitroimidazoles.Antimicrob Agents Chemother. 1976 Sep;10(3):476-82. doi: 10.1128/AAC.10.3.476. Antimicrob Agents Chemother. 1976. PMID: 791102 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
