doi: 10.1093/jnci/56.2.441.
Promoting effect of sodium deoxycholate on colon adenocarcinomas in germfree rats
- PMID: 1255778
- DOI: 10.1093/jnci/56.2.441
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Promoting effect of sodium deoxycholate on colon adenocarcinomas in germfree rats
J Natl Cancer Inst.
1976 Feb.
Abstract
The promoting effect of sodium deoxycholate (DC) on colon carcinogenesis was studied in female F344 germfree rats. Animals received intrarectal (ir) instillations of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 4 weeks (total dose, 16 mg/rat), then weekly ir doses of DC (total dose, 3 g/rat); the rats were autopsied 52 weeks after the first injection. DC increased the number of MNNG-induced colon adenocarcinomas. No tumors were in the colons of germfree rats given DC alone. It was concluded that DC (present in high concentrations in human stools) had a promoting effect on colon carcinogenesis in rats.
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