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Review
. 2003 Feb 1;326(7383):262-6.
doi: 10.1136/bmj.326.7383.262.

Pathogenesis of sepsis: new concepts and implications for future treatment

Pierre-Yves Bochud  1 , Thierry Calandra
Affiliations
Review

Pathogenesis of sepsis: new concepts and implications for future treatment

Pierre-Yves Bochud et al. BMJ. .
No abstract available

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Figures

Figure
Figure
Interaction between bacterial products and pattern recognition receptors expressed on immune cells. Components of bacterial cell walls (such as lipopolysaccharide, peptidoglycan, lipoteichoic acid, flagellin, and unmethylated CpG DNA sequences) interact with specific Toll-like receptors (TLR) expressed on immune cells. The receptors then activate intracellular signalling pathways and transcription factors resulting in expression of the gene for immune response
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References

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    1. Calandra T, Bochud PY, Heumann D. Cytokines in septic shock. In: Remington JS, Swartz MN, editors. Current clinical topics in infectious diseases. Oxford: Blackwell Publishing; 2002. pp. 1–23. - PubMed

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