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Case Reports
. 2002 Dec;43(12):971-2.

Nonsteroidal anti-inflammatory drug-induced duodenal ulceration and perforation in a mature rottweiler

Suma Reed  1
Affiliations
Case Reports

Nonsteroidal anti-inflammatory drug-induced duodenal ulceration and perforation in a mature rottweiler

Suma Reed. Can Vet J. 2002 Dec.

Abstract

A mature male rottweiler was evaluated for acute collapse and abdominal pain. The history consisted of concurrent administration of meloxicam and aspirin. On exploratory laparotomy, a large perforated ulcer was discovered in the proximal duodenum, with secondary peritonitis. The pathogenesis of NSAID-induced gastrointestinal ulceration and the supposed safety of COX-2 selective agents are discussed.

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References

    1. Reuter BK, Davies NM, Wallace JL. Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation. Gastroenterology 1997;112:109–117. - PubMed
    1. Forsyth SF, Guilford WG, Lawoko CRO. Endoscopic evaluation of the gastroduodenal mucosa following nonsteroidal anti-inflammatory drug administration in the dog. N Z Vet J 1996;44:179–181. - PubMed
    1. Yamada T, Deitch E, Specian RD, Perry MA, Sartor RB, Grisham MB. Mechanisms of acute and chronic intestinal inflammation induced by indomethacin. Inflammation 1993;17:641–662. - PubMed
    1. Gogny M. Pharmacological profile and therapeutic value of meloxicam. In: Bennett, David, ed. Proc Recent Advances in Non-Steroidal Anti-Inflammatory Therapy in Small Animals, Boehringer-Ingelheim, Paris, June 1999:35–40.
    1. Wallace JL. NSAID gastroenteropathy: Past, present and future. Can J Gastroenterol 1996;10:451–458. - PubMed

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