Review
doi: 10.1007/s11882-003-0029-2.
Neutrophils in asthma pathophysiology
Affiliations
- PMID: 12562556
- DOI: 10.1007/s11882-003-0029-2
Item in Clipboard
Review
Neutrophils in asthma pathophysiology
Curr Allergy Asthma Rep.
2003 Mar.
Abstract
Although the role of eosinophils, mast cells, and T cells in asthma has long been recognized, several reports suggest that neutrophils may also be involved. In most studies of people with mild asthma, neutrophil numbers in the airways are not different from controls. However, in severe asthma, including asthma deaths, neutrophils are usually raised. Furthermore, most pediatric studies suggest that neutrophils are raised in some children, in particular in the young or infantile wheeze group. Measurements of inflammatory mediators in the airways of asthmatic subjects suggest that neutrophils are activated.
Similar articles
-
Generation and partial characterization of eosinophil chemotactic activity and neutrophil chemotactic activity during early and late-phase asthmatic response.J Allergy Clin Immunol. 1986 Aug;78(2):282-90. doi: 10.1016/s0091-6749(86)80077-x. J Allergy Clin Immunol. 1986. PMID: 3734281
-
Neutrophils in asthma.Curr Allergy Asthma Rep. 2007 Nov;7(6):464-8. doi: 10.1007/s11882-007-0071-6. Curr Allergy Asthma Rep. 2007. PMID: 17986378 Review.
-
The role of eosinophils and neutrophils in inflammation.Clin Exp Allergy. 2000 Jun;30 Suppl 1:22-7. doi: 10.1046/j.1365-2222.2000.00092.x. Clin Exp Allergy. 2000. PMID: 10849470 Review.
-
Reduced activation of peripheral blood neutrophils after late-phase asthmatic responses but not in mild stable asthma.Respiration. 2001;68(5):471-9. doi: 10.1159/000050553. Respiration. 2001. PMID: 11694808
-
Eosinophil cationic protein and interleukin-8 levels in bronchial lavage fluid from children with asthma and infantile wheeze.Pediatr Allergy Immunol. 2001 Feb;12(1):27-33. doi: 10.1034/j.1399-3038.2001.012001027.x. Pediatr Allergy Immunol. 2001. PMID: 11251862
Cited by
-
Rare Chromone Derivatives from the Marine-Derived Penicillium citrinum with Anti-Cancer and Anti-Inflammatory Activities.Mar Drugs. 2021 Jan 8;19(1):25. doi: 10.3390/md19010025. Mar Drugs. 2021. PMID: 33430124 Free PMC article.
-
A new mouse model of lung allergy induced by the spores of Alternaria alternata and Cladosporium herbarum molds.Clin Exp Immunol. 2005 Feb;139(2):179-88. doi: 10.1111/j.1365-2249.2004.02679.x. Clin Exp Immunol. 2005. PMID: 15654816 Free PMC article.
-
Constituents from the Fruiting Bodies of Trametes cubensis and Trametes suaveolens in Vietnam and Their Anti-Inflammatory Bioactivity.Molecules. 2021 Dec 2;26(23):7311. doi: 10.3390/molecules26237311. Molecules. 2021. PMID: 34885893 Free PMC article.
-
New Labdane-type diterpenoids and anti-inflammatory constituents from Hedychium coronarium.Int J Mol Sci. 2013 Jun 25;14(7):13063-77. doi: 10.3390/ijms140713063. Int J Mol Sci. 2013. PMID: 23799360 Free PMC article.
-
Inhibition of superoxide anion and elastase release in human neutrophils by 3'-isopropoxychalcone via a cAMP-dependent pathway.Br J Pharmacol. 2006 May;148(1):78-87. doi: 10.1038/sj.bjp.0706712. Br J Pharmacol. 2006. PMID: 16501579 Free PMC article.