Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Feb;4(2):95-104.
doi: 10.1038/nrm1019.

NALPs: a novel protein family involved in inflammation

Jürg Tschopp  1 , Fabio Martinon, Kimberly Burns
Affiliations
Review

NALPs: a novel protein family involved in inflammation

Jürg Tschopp et al. Nat Rev Mol Cell Biol. 2003 Feb.

Abstract

A newly discovered family of cytoplasmic proteins--the NALPs--has been implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large, signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-inflammatory caspases.

PubMed Disclaimer

LinkOut - more resources