Tor signalling in bugs, brain and brawn
- PMID: 12563289
- DOI: 10.1038/nrm1018
Tor signalling in bugs, brain and brawn
Erratum in
- Nat Rev Mol Cell Biol. 2003 Mar;4(3):249
Abstract
TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors.
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