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. 2003 Mar;72(3):759-62.
doi: 10.1086/368230. Epub 2003 Jan 30.

Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q

S L Slager  1 , D J Schaid, J M Cunningham, S K McDonnell, A F Marks, B J Peterson, S J Hebbring, S Anderson, A J French, S N Thibodeau
Affiliations

Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q

S L Slager et al. Am J Hum Genet. 2003 Mar.

Abstract

Regions on chromosomes 7 and 19 were recently reported to contain susceptibility loci that regulate tumor aggressiveness of prostate cancer. To confirm these findings, we analyzed genome scan data from 161 pedigrees affected with prostate cancer. Using the Gleason score as a quantitative measure of tumor aggressiveness, we regressed the squared trait difference, as well as the mean-corrected cross product, on the estimated proportion of alleles shared identical-by-descent at each marker position. Our results confirm the previous linkage results for chromosome 19q (D19S902, P<.00001). In addition, we report suggestive evidence for linkage on chromosome 4 (D4S403, P=.00012). The results of previous findings, together with our results, provide strong evidence that chromosome 19 harbors a gene for tumor aggressiveness.

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Figures

Figure 1
Figure 1
Linkage scan for loci segregating with prostate tumor aggressiveness. The solid line denotes the original HE analysis (i.e., the trait-difference-squared); the broken dotted/dashed line denotes the revised HE analysis (i.e., trait-mean-corrected product). The horizontal dotted/dashed line in each subfigure indicates where P=.001 (-log[P]=3). Points above this line denote P<.001. Tick marks on the X-axis denote marker locations.
See this image and copyright information in PMC

References

Electronic-Database Information

    1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/Omim/ (for prostate cancer [MIM 176807])

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