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Comparative Study
. 2001 Jan;15(1):12-4.

[Study on adriamycin-porous tricalcium phosphate ceramic drug delivery system and its drug release test in vivo]

[Article in Chinese]
H B You  1 , A M Chen, S Z Sun
Affiliations
  • PMID: 12563920
Comparative Study

[Study on adriamycin-porous tricalcium phosphate ceramic drug delivery system and its drug release test in vivo]

[Article in Chinese]
H B You et al. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2001 Jan.

Abstract

Objective: To manufacture adriamycin-porous tricalcium phosphate (A-PTCP) ceramic drug delivery system (DDS) as a possible method for bone defect treatment after bone tumor operation.

Methods: A-PTCP DDS was made from putting adriamycin into PTCP. Thirty rabbits were divided randomly into group A(24 rabbits) and group B(6 rabbits). A-PTCP was implanted in the greater trochanter of the right femur in group A. Adriamycin were injected into veins in group B. Muscle around A-PTCP and plasma were taken out at different period. Adriamycin concentrations in muscle and plasma were measured by high performance liquid chromatography (HPLC).

Results: A-PTCP could gradually release adriamycin over 10 weeks. Adriamycin concentrations in the muscle were higher than that in plasma.

Conclusion: A-PTCP may be a new method for repairing bone defects after bone tumor operation.

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