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. 2002 Sep;16(5):319-21.

[Autocrine regulation for transforming growth factor-beta 1 by fibroblast in vitro]

[Article in Chinese]
Jie Zhang  1 , Ping Lin, Lu-gang Huang
Affiliations
  • PMID: 12569803

[Autocrine regulation for transforming growth factor-beta 1 by fibroblast in vitro]

[Article in Chinese]
Jie Zhang et al. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2002 Sep.

Abstract

Objective: To explore the autocrine regulation for the transforming growth factor-beta 1(TGF-beta 1) by the fibroblasts in vitro.

Methods: Fibroblasts were cultured in vitro which isolated from the normal prepuce by circumcision. TGF-beta 1 concentration were determined with ELISA for the different passages and the different time at the same passage.

Results: The TGF-beta 1 concentration was different for the distinct passage of fibroblasts and achieved the peak (450 ng/L) at the sixth passage. Among the same fibroblasts, the TGF-beta 1 concentration was different in the various days and passage of the summit (680 ng/L) on the fifth day, which was 2.5 times as high as that of the first day.

Conclusion: The fibroblasts possess the ability of autocrine of the TGF-beta 1 and have some regularity. It will provide the theory basis for the research about TGF-beta 1 regulation mechanism and the medical application about salvia miltiorrhiza.

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