Acute and chronic effects of 4-chloroamphetamine on monoamine metabolism in the rat brain
- PMID: 1257360
- DOI: 10.1007/BF00421543
Acute and chronic effects of 4-chloroamphetamine on monoamine metabolism in the rat brain
Abstract
The acute administration of 4-chloroamphetamine caused a marked reduction in the concentration of serotonin and 5-hydroxyindoleacetic acid and a rise in dopamine in the rat brain. Following the injection of 3H-tyrosine and 3H-tryptophane into rats treated with 4-chloroamphetamine, there was a reduction in brain levels of 3H-dopamine and 3H-serotonin. Although the endogenous concentration of noradrenaline was not affected by 4-chloroamphetamine, there is evidence that its reuptake into neurones was reduced and its release increased by the drug. Following the administration of 4-chloroamphetamine for 10 days, the concentration of 5-hydroxyindoleacetic acid was reduced; no other changes in amine metabolism were apparent. From this investigation, and those of others, it appears that following acute administration, 4-chloroamphetamine has a neurochemical profile which has a similarity to that of many tricyclic antidepressants. However, there is a marked discrepancy between the acute and chronic effects of 4-CA on brain amine metabolism. Such findings are difficult to reconcile with the widely accepted theory that antidepressant drugs counteract the symptoms of depression by increasing the concentration of noradrenaline and/or serotonin at receptor sites within the brain.
Similar articles
-
Differential effects of d-fenfluramine and p-chloroamphetamine on H75/12-induced depletion of 5-hydroxytryptamine and dopamine in the rat brain.Neuropharmacology. 1991 Jan;30(1):15-23. doi: 10.1016/0028-3908(91)90037-c. Neuropharmacology. 1991. PMID: 1710793
-
Some effects of a new tetracyclic anti-depressant compound, Org GB 94, on the metabolism of monoamines in the rat brain.Psychopharmacologia. 1974 Apr 23;36(3):221-36. doi: 10.1007/BF00421804. Psychopharmacologia. 1974. PMID: 4846327 No abstract available.
-
Comparison of 1-methyl-4-(p-chlorophenyl)-1,2,3,6-tetrahydropyridine, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and p-chloroamphetamine as monoamine depletors.Res Commun Chem Pathol Pharmacol. 1985 Oct;50(1):57-65. Res Commun Chem Pathol Pharmacol. 1985. PMID: 2417293
-
Immediate and long-term effects of p-chloroamphetamine on brain amines.Ann N Y Acad Sci. 1978 Jun 12;305:208-21. doi: 10.1111/j.1749-6632.1978.tb31525.x. Ann N Y Acad Sci. 1978. PMID: 360935 Review. No abstract available.
-
Actions of drugs that deplete serotonin.Fed Proc. 1977 Jul;36(8):2149-53. Fed Proc. 1977. PMID: 141378 Review. No abstract available.
Cited by
-
Backward walking and circling: behavioural responses induced by drug treatments which cause simultaneous release of catecholamines and 5-hydroxytryptamine.Br J Pharmacol. 1979 Aug;66(4):573-9. doi: 10.1111/j.1476-5381.1979.tb13696.x. Br J Pharmacol. 1979. PMID: 465894 Free PMC article.
-
Concurrent determination of effects of p-chloroamphetamine on central extracellular 5-hydroxytryptamine concentration and behaviour.Br J Pharmacol. 1989 Apr;96(4):801-6. doi: 10.1111/j.1476-5381.1989.tb11887.x. Br J Pharmacol. 1989. PMID: 2472844 Free PMC article.
-
Amphetamine derivatives induce locomotor hyperactivity by acting as indirect serotonin agonists.Psychopharmacology (Berl). 1991;104(3):293-301. doi: 10.1007/BF02246026. Psychopharmacology (Berl). 1991. PMID: 1924637