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Clinical Trial
. 2003 Feb;250(2):222-5.
doi: 10.1007/s00415-003-0983-6.

Accuracy of diffusion-weighted MR imaging in the diagnosis of sporadic Creutzfeldt-Jakob disease

Philippe Demaerel  1 , Raf Sciot, Wim Robberecht, René Dom, Dirk Vandermeulen, Frederik Maes, Guido Wilms
Affiliations
Clinical Trial

Accuracy of diffusion-weighted MR imaging in the diagnosis of sporadic Creutzfeldt-Jakob disease

Philippe Demaerel et al. J Neurol. 2003 Feb.

Abstract

The definitive diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) is based on brain autopsy. The 14-3-3 analysis in the CSF is considered a highly sensitive and specific procedure. Sensitivity, specificity and accuracy of EEG, the 14-3-3 assay and MR imaging in 12 patients referred for suspected sCJD were calculated. We suggest that diffusion-weighted MR imaging (DWI) should be included in the array of diagnostic tests because of the 100 % sensitivity and specificity.

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