Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Aug;21(8):591-4.

[Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model]

[Article in Chinese]
H Xu  1 , D Z Shi, K J Chen
Affiliations
  • PMID: 12575573

[Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model]

[Article in Chinese]
H Xu et al. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Aug.

Abstract

Objective: To study the effect of Xiongshao Capsule (XS) on vascular remodeling in porcine coronary balloon injury model.

Methods: Restenosis model was established by oversized balloon injury at mid-region of the left anterior descending coronary artery. The effect of drugs on late lumen loss and vascular remodeling was evaluated with quantitative histological method by combining results from histopathological analysis and coronary arteriography.

Results: Vascular remodeling explained (59 +/- 20)% of late lumen loss. All drugs significantly reduced late lumen loss 4 weeks after balloon injury (P < 0.05 or 0.01). Both low-dose and high-dose XS markedly reduced late lumen loss resulting from vascular remodeling, as compared with the control group (P < 0.05 and P < 0.01 respectively).

Conclusion: Vascular remodeling played an important role in late lumen stenosis after balloon injury of coronary artery. XS could significantly inhibit pathological vascular remodeling after balloon injury, thus reduce late lumen loss and prevent restenosis.

PubMed Disclaimer

Publication types