It takes two to tango, but three to ISA
- PMID: 12575944
- DOI: 10.1016/s0896-6273(03)00060-6
It takes two to tango, but three to ISA
Abstract
Rapidly inactivating A-type potassium channels are important determinants of firing frequency in many excitable cells. Nadal et al. (in this issue of Neuron) purified A-type potassium (I(SA)) channels from rat cerebellum and identified a novel beta subunit. This protein, DPPX, associates with the pore-forming subunits and endows previously elusive kinetic properties on A-type channels formed from cloned subunits.
Comment on
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The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels.Neuron. 2003 Feb 6;37(3):449-61. doi: 10.1016/s0896-6273(02)01185-6. Neuron. 2003. PMID: 12575952
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