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. 1976 Jan;13(1):9-18.

New method for detecting and quantitating pharmacokinetic drug-drug interactions applied to ethanol-propranolol

J G Wagner, D J Weidler, Y J Lin
  • PMID: 1257604

New method for detecting and quantitating pharmacokinetic drug-drug interactions applied to ethanol-propranolol

J G Wagner et al. Res Commun Chem Pathol Pharmacol. 1976 Jan.

Abstract

A novel method for detecting and quantitating pharmacokinetic drug-drug interactions is described. The method involves perturbation of an existing steady-state whole blood (or plasma) concentration of one drug by the other drug. The method would allow differentiation of "pharmacokinetic" drug interactions from "pharmacologic" interactions. It is shown that a bolus intravenous injection of propranolol reduced a steady-state arterial blood concentration of ethyl alcohol by 26% in the cat.

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