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. 2003 Mar;33(3):339-41.
doi: 10.1038/ng1102. Epub 2003 Feb 10.

Coordination of the random asynchronous replication of autosomal loci

Nandita Singh  1 , Farah A W Ebrahimi, Alexander A Gimelbrant, Alexander W Ensminger, Michael R Tackett, Peimin Qi, Joost Gribnau, Andrew Chess
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Coordination of the random asynchronous replication of autosomal loci

Nandita Singh et al. Nat Genet. 2003 Mar.

Abstract

Random monoallelic expression and asynchronous replication define an unusual class of autosomal mammalian genes. We show that every cell has randomly chosen either the maternal or paternal copy of each given autosome pair, such that alleles of these genes scattered across the chosen chromosome replicate earlier than the alleles on the homologous chromosome. Thus, chromosome-pair non-equivalence, rather than being limited to X-chromosome inactivation, is a fundamental property of mouse chromosomes.

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  • Connecting the dots.
    Packer A. Packer A. Nat Genet. 2003 Mar;33(3):332. doi: 10.1038/ng0303-332. Nat Genet. 2003. PMID: 12610546 No abstract available.

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