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. 1976 Apr 2;192(4234):53-4.
doi: 10.1126/science.1257755.

Nonenzymic joining of oligoadenylates on a polyuridylic acid template

D A Usher, A H McHale

Nonenzymic joining of oligoadenylates on a polyuridylic acid template

D A Usher et al. Science. .

Abstract

3',5'-Linked hexa-adenylic acid with a 2',3'-cyclic phosphate terminus [(A5A less than p] couples on a polyuridylic acid template in the presence of ethylenediamine to form the dodecamer (24 percent) and octadecamer (5 percent). The bond produced is largely that of the 2',5' isomer.

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