doi: 10.1126/science.1257777.
d-Amphetamine-induced inhibition of central dopaminergic neurons: mediation by a striato-nigral feedback pathway
- PMID: 1257777
- DOI: 10.1126/science.1257777
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d-Amphetamine-induced inhibition of central dopaminergic neurons: mediation by a striato-nigral feedback pathway
Science.
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Abstract
Lesions of the striato-nigral pathways (that is, crus cerebri or vicinity of the tail of the caudate nucleus) markedly attenuate depressant effects of intravenous d-amphetamine on central dopaminergic cell activity. These results, coupled with previous data showing that microiontophoretic application of d-amphetamine directly onto dopaminergic cells does not produce significant slowing, provide direct support for the hypothesis that the depressant effect of d-amphetamine on these cells is mediated through a striato-nigral neuronal feedback loop.
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