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Review
. 2003 Feb;44(1):1-7; quiz 8-9.
doi: 10.1046/j.1440-0960.2003.06301.x.

Epidemiology and pathogenesis of scleroderma

Keng Chen  1 , Adrian See, Stephen Shumack
Affiliations
Review

Epidemiology and pathogenesis of scleroderma

Keng Chen et al. Australas J Dermatol. 2003 Feb.

Abstract

Scleroderma is a heterogenous connective tissue disorder characterized by fibrosis of the skin, with or without internal organ involvement. The aetiology of scleroderma may involve both environmental and genetic factors. Abnormalities involving the immune system, vascular tissue and extracellular matrix have been demonstrated. Recent research has focused on microchimerism as a risk factor for the development of scleroderma. This article reviews the epidemiology and pathogenesis of this disorder.

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