Review
doi: 10.1016/s0959-440x(02)00006-4.
DNA manipulators: caught in the act
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- PMID: 12581655
- DOI: 10.1016/s0959-440x(02)00006-4
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Review
DNA manipulators: caught in the act
Curr Opin Struct Biol.
2003 Feb.
Abstract
DNA is a dynamic molecule that undergoes constant changes in the cell through interactions with numerous proteins. Several classes of enzyme are specialized in promoting DNA rearrangements, including site-specific recombinases, DNA helicases, transposases and DNA topoisomerases. Recent structures of protein-DNA reaction intermediates trapped in various states of DNA remodeling, complemented by biochemical and biophysical functional studies, have enhanced our understanding of their respective mechanistic pathways.
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