Review
doi: 10.1016/s0959-440x(03)00011-3.
Single-molecule folding
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- PMID: 12581665
- DOI: 10.1016/s0959-440x(03)00011-3
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Review
Single-molecule folding
Curr Opin Struct Biol.
2003 Feb.
Abstract
Recent developments in fluorescence and force spectroscopy enable us to go beyond the ensemble average and measure the behavior of individual biomacromolecules. These single-molecule approaches can directly resolve transient intermediate states and multiple reaction pathways, and thus are uniquely powerful in characterizing the complex dynamics of biological processes. Recent applications of these two techniques to the protein and RNA folding problems have led to exciting new results.
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