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. 2003 Feb 12;19(3):336-44.
doi: 10.1093/bioinformatics/btf851.

Genetic Network Analyzer: qualitative simulation of genetic regulatory networks

Hidde de Jong  1 , Johannes Geiselmann, Céline Hernandez, Michel Page
Affiliations

Genetic Network Analyzer: qualitative simulation of genetic regulatory networks

Hidde de Jong et al. Bioinformatics. .

Abstract

Motivation: The study of genetic regulatory networks has received a major impetus from the recent development of experimental techniques allowing the measurement of patterns of gene expression in a massively parallel way. This experimental progress calls for the development of appropriate computer tools for the modeling and simulation of gene regulation processes.

Results: We present Genetic Network Analyzer (GNA), a computer tool for the modeling and simulation of genetic regulatory networks. The tool is based on a qualitative simulation method that employs coarse-grained models of regulatory networks. The use of GNA is illustrated by a case study of the network of genes and interactions regulating the initiation of sporulation in Bacillus subtilis.

Availability: GNA and the model of the sporulation network are available at http://www-helix.inrialpes.fr/gna.

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