Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Feb;142(2):149-54.
doi: 10.1067/mpd.2003.46.

Altered myocardial flow reserve and endothelial function late after Kawasaki disease

Hideto Furuyama  1 , Yasuhisa Odagawa, Chietsugu Katoh, Yasuyoshi Iwado, Yoshinori Ito, Kazuyuki Noriyasu, Megumi Mabuchi, Keiichirou Yoshinaga, Yuji Kuge, Kunihiko Kobayashi, Nagara Tamaki
Affiliations

Altered myocardial flow reserve and endothelial function late after Kawasaki disease

Hideto Furuyama et al. J Pediatr. 2003 Feb.

Abstract

Objectives: Coronary arterial lesions after Kawasaki disease (KD) may cause coronary endothelial dysfunction as the result of intimal hypertrophy. Our purpose was to assess myocardial flow reserve (MFR) and endothelial function in various myocardial regions after KD by using positron emission tomography.

Study design: Twenty-seven patients, 17.2 +/- 3.2 years of age, who had KD at 1.9 +/- 1.4 years, and 12 normal healthy subjects, 26.5 +/- 3.4 years of age, were evaluated by means of myocardial blood flow (MBF) with (15)O-water positron emission tomography. MFR was estimated by MBF changes under adenosine triphosphate infusion and endothelial function by MBF changes under cold pressor testing. The left ventricle was divided into three coronary territories. Ten stenotic regions, 20 aneurysmal regions, 30 regressed aneurysmal regions, and 21 regions without coronary arterial lesions were compared with 36 control regions of the normal volunteers.

Results: MBF at rest was similar in each region. Hyperemic blood flow and MFR in each region after KD was significantly lower than those in the regions of normal volunteers. MBF during cold pressor testing was significantly reduced in each region after KD, as compared with no change in the control regions.

Conclusions: Our study indicates impaired MFR and endothelial function regardless of coronary artery status after KD.

PubMed Disclaimer

MeSH terms