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. 1976 Jan-Feb:(1):57-62.

[Activity of DNA-dependent RNA polymerases A and B in spleen nuclei of mice infected with Rauscher leukemia virus]

[Article in Russian]
T V Veselovskaia, N F Pravdina, G A Galegov, V M Zhdanov
  • PMID: 1258455

[Activity of DNA-dependent RNA polymerases A and B in spleen nuclei of mice infected with Rauscher leukemia virus]

[Article in Russian]
T V Veselovskaia et al. Vopr Virusol. 1976 Jan-Feb.

Abstract

The activity of DNA-dependent RNA polymerase A and B in isolated nuclei of spleens of mice infected with Rauscher leukemia virus was studied. A 3-fold increase in the activity of both RNA-polymerases in leukemic spleens was established. Study of the properties of RNA-polymerase B from nuclei of spleens of mice infected with Rauscher virus in comparison with the enzyme from normal tissue revealed the existence of some specific features in the enzyme from leukemic cells. The nature of the increased activity of RNA-polymerase B in leukemic cells is discussed.

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