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Comment
. 2003 Feb 17;197(4):397-401.
doi: 10.1084/jem.20030012.

Control of immune responses by naturally arising CD4+ regulatory T cells that express toll-like receptors

Shimon Sakaguchi  1
Affiliations
Comment

Control of immune responses by naturally arising CD4+ regulatory T cells that express toll-like receptors

Shimon Sakaguchi. J Exp Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Signaling to CD25+ CD4+ TR cells via several cell surface molecules including TCR, CD28, CTLA-4, GITR, IL-2 R (CD25), and TLRs results in augmentation or attenuation of their suppressive activity. During the proliferation of TR cells in the presence of high dose IL-2 along with TCR stimulation, they lose suppressive activity whereas they show augmented suppressive activity upon withdrawal of IL-2 after expansion (references and 23). TLR stimulation may also show a similar sequence of events, i.e., loss of suppressive activity during proliferation and augmented suppression after expansion.
Figure 2.
Figure 2.
At least some of CD25+ CD4+ TR cells are produced by the normal thymus as a functionally mature T cell subpopulation. They specifically express the Foxp3 gene. Reduction of CD25+ CD4+ TR cells or attenuation of their suppressive activity by manipulating various molecules shown in Fig. 1 may elicit autoimmunity or enhance autoimmunity, tumor immunity, microbial immunity, or allergy. In contrast, an increase of the number of TR cells or augmentation of their suppressive activity can delay the rejection of organ grafts and induce transplantation tolerance.
See this image and copyright information in PMC

Comment on

References

    1. Cohn, M. 1994. The wisdom of hindsight. Annu. Rev. Immunol. 12:1–62. - PubMed
    1. Medzhitov, R., and C.A. Janeway, Jr. 2002. Decoding the patterns of self and nonself by the innate immune system. Science. 296:298–300. - PubMed
    1. Matzinger, P. 2002. The danger model: a renewed sense of self. Science. 296:301–305. - PubMed
    1. Sakaguchi, S., N. Sakaguchi, J. Shimizu, S. Yamazaki, T. Sakihama, M. Itoh, Y. Kuniyasu, T. Nomura, M. Toda, and T. Takahashi. 2001. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182:18–32. - PubMed
    1. Shevach, E.M. 2001. Certified professionals: CD4+CD25+ suppressor T cells. J. Exp. Med. 193:F41–F46. - PMC - PubMed

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