Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Mar;9(3):277-9.
doi: 10.1261/rna.2183803.

A uniform system for microRNA annotation

Victor Ambros  1 , Bonnie Bartel, David P Bartel, Christopher B Burge, James C Carrington, Xuemei Chen, Gideon Dreyfuss, Sean R Eddy, Sam Griffiths-Jones, Mhairi Marshall, Marjori Matzke, Gary Ruvkun, Thomas Tuschl
Affiliations

A uniform system for microRNA annotation

Victor Ambros et al. RNA. 2003 Mar.

Abstract

MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that miRNAs can be reliably distinguished from other RNAs such as small interfering RNAs. We describe specific criteria for the experimental verification of miRNAs, and conventions for naming miRNAs and miRNA genes. Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families.

PubMed Disclaimer

References

    1. Griffiths-Jones, S., Bateman, A., Marshall, M., Khanna, A., and Eddy, S.R. 2003. Rfam: An RNA family database. Nucleic Acids Res. 31: 439–441. - PMC - PubMed
    1. Hutvagner, G. and Zamore, P.D. 2002. A microRNA in a multiple-turnover RNAi enzyme complex.Science 297: 2056–2060. - PubMed
    1. Lagos-Quintana, M., Rauhut, R., Lendeckel, W., and Tuschl, T.2001. Identification of novel genes coding for small expressed RNAs. Science 294: 853–858. - PubMed
    1. Lau, N.C., Lim, L.P., Weinstein, E.G., and Bartel, D.P. 2001. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294: 858–862. - PubMed
    1. Lee, R.C., Feinbaum, R.L., and Ambros, V. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.Cell 75: 843–854. - PubMed

MeSH terms

LinkOut - more resources