Review
doi: 10.1016/s1286-4579(02)00057-6.
The NKG2D receptor and its ligands-recognition beyond the "missing self"?
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- PMID: 12593971
- DOI: 10.1016/s1286-4579(02)00057-6
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Review
The NKG2D receptor and its ligands-recognition beyond the "missing self"?
Microbes Infect.
2003 Jan.
Free article
Abstract
NKG2D is a surface receptor that activates natural killer (NK) cells and delivers a co-stimulatory signal to CD8-positive T cells. The ligands of NKG2D are induced by cellular stress and are specifically expressed by some tumor cells. This sparked the idea of an alternative regulation of NK cells by expression of "induced self" ligands on target cells which can overcome the inhibition imparted by MHC class I-specific inhibitory receptors.
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