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Review
. 2003 Feb;13(1):70-8.
doi: 10.1016/s0959-4388(03)00002-3.

Development and maintenance of neuronal architecture at the ventral midline of C. elegans

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Review

Development and maintenance of neuronal architecture at the ventral midline of C. elegans

Oliver Hobert et al. Curr Opin Neurobiol. 2003 Feb.

Abstract

Work in flies, nematodes and vertebrates has shown that genes involved in axon patterning at the ventral midline are functionally conserved across phylogeny. Recent studies in Caenorhabditis elegans have implicated several new extracellular molecules, such as nidogen and heparan sulfate proteoglycans, in axonal tract formation at the midline. Furthermore, a conceptually new mechanism that regulates the maintenance of axon positioning at the midline has been described in C. elegans.

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