Review
doi: 10.1016/s0959-4388(03)00008-4.
Assembly and plasticity of the glutamatergic postsynaptic specialization
Affiliations
- PMID: 12593989
- DOI: 10.1016/s0959-4388(03)00008-4
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Review
Assembly and plasticity of the glutamatergic postsynaptic specialization
Curr Opin Neurobiol.
2003 Feb.
Abstract
Glutamate mediates most excitatory synaptic transmission in the brain. Synaptic strength at glutamatergic synapses shows a remarkable degree of use-dependent plasticity and such modifications may represent a physiological correlate to learning and memory. Glutamate receptors and downstream enzymes are organized at synapses by cytoskeletal proteins containing multiple protein-interacting domains. Recent studies demonstrate that these 'scaffolding' proteins within the postsynaptic specialization have the capacity to promote synaptic maturation, influence synapse size, and modulate glutamate receptor function.
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