Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Mar;71(3):1574-9.
doi: 10.1128/IAI.71.3.1574-1579.2003.

Nonhuman primate model for Listeria monocytogenes-induced stillbirths

Mary Alice Smith  1 , Kazue Takeuchi, Robert E Brackett, Harold M McClure, Richard B Raybourne, Kristina M Williams, Uma S Babu, Glenn O Ware, J Roger Broderson, Michael P Doyle
Affiliations

Nonhuman primate model for Listeria monocytogenes-induced stillbirths

Mary Alice Smith et al. Infect Immun. 2003 Mar.

Abstract

Listeria monocytogenes, isolated from outbreaks in either human or nonhuman primate populations, was administered orally at doses ranging from 10(6) to 10(10) CFU. Four of 10 treated animals delivered stillborn infants. L. monocytogenes was isolated from fetal tissue, and the pathology was consistent with L. monocytogenes infection as the cause of pregnancy loss. For all pregnancies resulting in stillbirths, L. monocytogenes was isolated from maternal feces, indicating that L. monocytogenes had survived and had probably colonized the gastrointestinal tract. Antibodies and antigen-specific lymphocyte proliferation against Listeria increased in animals that had stillbirths.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Antigen-induced proliferation of peripheral blood lymphocytes. Proliferative response to heat-killed L. monocytogenes strain 12443 was measured by [3H]thymidine incorporation after 72 h of culture. Bars represent the mean responses ± standard errors of results for animals with normal pregnancy outcomes (filled bars; number of samples, 5) or stillbirths (empty bars; number of samples, 4). Proliferation responses were measured in samples collected immediately prior to infection and approximately 30 days after stillbirth or normal outcome of pregnancy. An asterisk indicates a result that is significantly different from the preinfection level at a P value of <0.05.
See this image and copyright information in PMC

References

    1. Anderson, D. C., and H. M. McClure. 1993. Listeriosis, p. 135-141. In T. C. Jones, U. Mohr, and L. D. Hunt (ed.), Nonhuman primates, vol. I. Monograph on pathology of laboratory animals. Springer-Verlag, New York, N.Y.
    1. Bula, C. J., J. Bille, and M. P. Glauser. 1995. An epidemic of food-borne listeriosis in western Switzerland: description of 57 cases involving adults. Clin. Infect. Dis. 20:66-72. - PubMed
    1. Centers for Disease Control and Prevention. 1998. Multistate outbreak of listeriosis—United States, 1998. Morb. Mortal. Wkly. Rep. 47:1085-1086. - PubMed
    1. Chalifoux, L. V., and E. M. Hajema. 1981. Septicemia and meningoencephalitis caused by Listeria monocytogenes in neonatal Macaca fascicularis. J. Med. Primatol. 10:336-339. - PubMed
    1. Cook, L. V. 1998. Isolation and identification of Listeria monocytogenes from red meat, poultry, egg and environmental samples, Sect. 8.1-8.9. In B. P. Dey and C. P. Lattuada (ed.), USDA/FSIS microbiology laboratory guide book. Food Safety and Inspection Service, U.S. Department of Agriculture, Washington, D.C.

Publication types

Substances