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. 2003 Mar;71(3):1604-7.
doi: 10.1128/IAI.71.3.1604-1607.2003.

Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated Neisseria meningitidis from phagocytosis by human monocytes/macrophages

Kate L R Dunn  1 , Jayne L Farrant, Paul R Langford, J Simon Kroll
Affiliations

Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated Neisseria meningitidis from phagocytosis by human monocytes/macrophages

Kate L R Dunn et al. Infect Immun. 2003 Mar.

Abstract

Superoxide dismutase cofactored by copper and zinc ([Cu,Zn]-SOD) contributes to the protection of opsonized serogroup B Neisseria meningitidis against phagocytosis by human monocytes/macrophages, with sodC mutant organisms being endocytosed in significantly higher numbers than are wild-type organisms. The influence of [Cu,Zn]-SOD was found to be exerted at the stage of phagocytosis, rather than at earlier (modulating surface association) or later (intracellular killing) stages.

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Figures

FIG. 1.
FIG. 1.
Intracellular survival of opsonized encapsulated (A) and nonencapsulated (B) sodC+ (open symbols) and sodC mutant (filled symbols) meningococci in human monocytes. Bacteria were incubated with human monocytes for 1 h, and then extracellular organisms were eliminated by washing and incubation with gentamicin. Intracellular bacteria were enumerated at intervals after the incubation with gentamicin, and the percent survival was determined.
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