Addictive drugs and stress trigger a common change at VTA synapses
- PMID: 12597851
- DOI: 10.1016/s0896-6273(03)00087-4
Addictive drugs and stress trigger a common change at VTA synapses
Abstract
In this issue of Neuron, Saal et al. find that exposure to any of five addictive drugs or exposure to a brief stressor produces a shared cellular modification of excitatory synapses in the ventral tegmental area (VTA). This common response may represent a starting point for dissecting early changes that underlie addiction.
Comment on
-
Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons.Neuron. 2003 Feb 20;37(4):577-82. doi: 10.1016/s0896-6273(03)00021-7. Neuron. 2003. PMID: 12597856
Similar articles
-
Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons.Neuron. 2003 Feb 20;37(4):577-82. doi: 10.1016/s0896-6273(03)00021-7. Neuron. 2003. PMID: 12597856
-
Nicotine potentiation of excitatory inputs to ventral tegmental area dopamine neurons.J Neurosci. 2011 May 4;31(18):6710-20. doi: 10.1523/JNEUROSCI.5671-10.2011. J Neurosci. 2011. PMID: 21543600 Free PMC article.
-
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons.Nature. 2001 May 31;411(6837):583-7. doi: 10.1038/35079077. Nature. 2001. PMID: 11385572
-
Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?Trends Neurosci. 2002 Dec;25(12):610-5. doi: 10.1016/s0166-2236(02)02289-0. Trends Neurosci. 2002. PMID: 12446127 Review.
-
Learning mechanisms in addiction: synaptic plasticity in the ventral tegmental area as a result of exposure to drugs of abuse.Annu Rev Physiol. 2004;66:447-75. doi: 10.1146/annurev.physiol.66.032102.112534. Annu Rev Physiol. 2004. PMID: 14977410 Review.
Cited by
-
Inhibitory effect of NMDA receptors in the ventral tegmental area on hormonal and eating behavior responses to stress in rats.Behav Neurol. 2014;2014:294149. doi: 10.1155/2014/294149. Epub 2014 Aug 7. Behav Neurol. 2014. PMID: 25177106 Free PMC article.
-
Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors.J Neurosci. 2006 Aug 16;26(33):8549-58. doi: 10.1523/JNEUROSCI.5179-05.2006. J Neurosci. 2006. PMID: 16914681 Free PMC article.
-
Stress enables synaptic depression in CA1 synapses by acute and chronic morphine: possible mechanisms for corticosterone on opiate addiction.J Neurosci. 2004 Mar 10;24(10):2412-20. doi: 10.1523/JNEUROSCI.5544-03.2004. J Neurosci. 2004. PMID: 15014116 Free PMC article.
-
Neuroplasticity in the mesolimbic system induced by natural reward and subsequent reward abstinence.Biol Psychiatry. 2010 May 1;67(9):872-9. doi: 10.1016/j.biopsych.2009.09.036. Epub 2009 Dec 16. Biol Psychiatry. 2010. PMID: 20015481 Free PMC article.
-
Ih blockade reduces cocaine-induced firing patterns of putative dopaminergic neurons of the ventral tegmental area in the anesthetized rat.Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jan 10;112:110431. doi: 10.1016/j.pnpbp.2021.110431. Epub 2021 Aug 27. Prog Neuropsychopharmacol Biol Psychiatry. 2022. PMID: 34454991 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources