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. 2003 Mar 1;187(5):869-71.
doi: 10.1086/367899. Epub 2003 Feb 18.

Outbreak of meningococcal disease caused by PorA-deficient meningococci

A van der Ende  1 , C T P Hopman, W C M Keijzers, L Spanjaard, E B Lodder, P H J van Keulen, J Dankert
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Outbreak of meningococcal disease caused by PorA-deficient meningococci

A van der Ende et al. J Infect Dis. .

Abstract

An outbreak of 7 cases of group C meningococcal disease occurred during the last week of July and the first week of August 2001 in the southwestern part of The Netherlands. Characterization of the 7 patients' isolates by various typing methods showed that the isolates were identical, except for the expression of PorA. Isolates from 5 patients were PorA deficient. These results show that transmission of PorA-deficient meningococci occurs and that PorA-deficient meningococci can cause invasive disease. PorA-based meningococcal vaccines may provide limited protection.

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