Major lipid classes in plasma membrane isolated from liver of rats fed a hepatocarcinogen

Abstract

More phosphatidylethanolamine and less phosphatidylinositol were present in the lipid of plasma membrane isolated from the liver of rats fed a diet containing the hepatocarcinogen, N-2-fluorenylacetamide than were present in the lipid of plasma membrane isolated from the liver of rats fed the basal diet. Phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin from the former membranes had relative amounts of 18 : 1 in their fatty acyl profiles that were 1.5--1.7 times the relative amount of 18 : 1 in the same phospholipid from the latter membranes. Furthermore, the former membranes contained 1.3 times more cholesterol and 1.35 times more sphingomyelin than the latter membrames.