Considering nuclear compartmentalization in the light of nuclear dynamics
- PMID: 12600306
- DOI: 10.1016/s0092-8674(03)00078-3
Considering nuclear compartmentalization in the light of nuclear dynamics
Abstract
Many proteins are concentrated in compartments within the nucleus. Chromatin is also compartmentalized at different nuclear sites. However, nuclear proteins have now been shown to be highly mobile. This review considers the formation and function of nuclear compartments in a situation in which proteins are rapidly moving through the nuclear volume.
Similar articles
-
The contribution of nuclear compartmentalization to gene regulation.Cell. 2002 Feb 22;108(4):513-21. doi: 10.1016/s0092-8674(02)00650-5. Cell. 2002. PMID: 11909522 Review.
-
The Role of Liquid-Liquid Phase Separation in the Compartmentalization of Cell Nucleus and Spatial Genome Organization.Biochemistry (Mosc). 2020 Jun;85(6):643-650. doi: 10.1134/S0006297920060012. Biochemistry (Mosc). 2020. PMID: 32586227 Review.
-
Protein dynamics: implications for nuclear architecture and gene expression.Science. 2001 Feb 2;291(5505):843-7. doi: 10.1126/science.291.5505.843. Science. 2001. PMID: 11225636 Review. No abstract available.
-
Chromatin and nuclear architecture in the nervous system.Trends Neurosci. 2008 Jul;31(7):343-52. doi: 10.1016/j.tins.2008.03.005. Epub 2008 Jun 4. Trends Neurosci. 2008. PMID: 18538423 Review.
-
Dynamic organization of transcription compartments is dependent on functional nuclear architecture.Biophys J. 2012 Sep 5;103(5):851-9. doi: 10.1016/j.bpj.2012.06.036. Biophys J. 2012. PMID: 23009834 Free PMC article.
Cited by
-
Host Factors in Retroviral Integration and the Selection of Integration Target Sites.Microbiol Spectr. 2014 Dec;2(6):10.1128/microbiolspec.MDNA3-0026-2014. doi: 10.1128/microbiolspec.MDNA3-0026-2014. Microbiol Spectr. 2014. PMID: 26104434 Free PMC article. Review.
-
Condensed chromatin domains in the mammalian nucleus are accessible to large macromolecules.EMBO Rep. 2003 Sep;4(9):861-6. doi: 10.1038/sj.embor.embor922. Epub 2003 Aug 22. EMBO Rep. 2003. PMID: 12947417 Free PMC article.
-
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences.PLoS Biol. 2004 Aug;2(8):E234. doi: 10.1371/journal.pbio.0020234. Epub 2004 Aug 17. PLoS Biol. 2004. PMID: 15314653 Free PMC article.
-
The three-dimensional structure of human interphase chromosomes is related to the transcriptome map.Mol Cell Biol. 2007 Jun;27(12):4475-87. doi: 10.1128/MCB.00208-07. Epub 2007 Apr 9. Mol Cell Biol. 2007. PMID: 17420274 Free PMC article.
-
Transcription factories: gene expression in unions?Nat Rev Genet. 2009 Jul;10(7):457-66. doi: 10.1038/nrg2592. Nat Rev Genet. 2009. PMID: 19506577 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases