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. 2003 Mar;53(3):413-6.
doi: 10.1002/ana.10509.

Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study

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Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study

Darren Fuerst et al. Ann Neurol. 2003 Mar.

Abstract

Twelve patients with refractory temporal lobe epilepsy and unilateral hippocampal sclerosis had repeat volumetric magnetic resonance imaging scans after a mean of 3.4 years to determine whether progressive hippocampal volume loss occurred. Seizure-free patients showed no change in hippocampal volume. Patients with continuing seizures had a decline in ipsilateral hippocampal volume that correlated with seizure frequency. Patients with medically refractory temporal lobe epilepsy and unilateral hippocampal sclerosis have progressive hippocampal atrophy.

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