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. 2003 Feb;9(2):258-61.
doi: 10.3201/eid0902.020142.

Invasive type e Haemophilus influenzae disease in Italy

Marina Cerquetti  1 , Marta Luisa Ciofi degli Atti, Rita Cardines, Stefania Salmaso, Giovanna Renna, Paola Mastrantonio; Hi Study Group
Affiliations

Invasive type e Haemophilus influenzae disease in Italy

Marina Cerquetti et al. Emerg Infect Dis. 2003 Feb.

Abstract

We describe the first reported cases of invasive type e Haemophilus influenzae disease in Italy. All five cases occurred in adults. The isolates were susceptible to ampicillin and eight other antimicrobial agents. Molecular analysis showed two distinct type e strains circulating in Italy, both containing a single copy of the capsulation locus.

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Figures

Figure
Figure
Pulsed-field gel electrophoresis patterns of ApaI-digested chromosomal DNAs of Haemophilus influenzae isolates. Lanes 1–5, H. influenzae type e (Hie) isolates, respectively, from patient nos. 1–5; lane 6, H. influenzae type b (Hib) strain belonging to one of the subclones endemic in Italy (9); M, λ ladder pulsed-field gel marker with molecular weights indicated in kilobases (kb) at the right. The isolates in lanes 3, 4, and 5 showed indistinguishable profiles (pattern 1); the isolate in lane 1 was closely related to pattern 1 (pattern 1a), whereas the isolate in lane 2 was clearly different from pattern 1 (pattern 2). All Hie isolates were unrelated to the Hib strain.
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