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Review
. 2003 Mar;47(3):837-46.
doi: 10.1128/AAC.47.3.837-846.2003.

FemABX peptidyl transferases: a link between branched-chain cell wall peptide formation and beta-lactam resistance in gram-positive cocci

S Rohrer  1 , B Berger-Bächi
Affiliations
Review

FemABX peptidyl transferases: a link between branched-chain cell wall peptide formation and beta-lactam resistance in gram-positive cocci

S Rohrer et al. Antimicrob Agents Chemother. 2003 Mar.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Pathway and inhibitors of peptidoglycan synthesis in S. aureus (adapted in part from references and 111). (I) The assembly of the lipid II precursor is universal for eubacteria; the MurA reaction is the first step committed to peptidoglycan synthesis (17, 111). (II) The interpeptide is synthesized on the membrane-bound precursor. (III and IV) Extracellular steps catalyzed by transglycosylases and transpeptidases (PBPs) lead to mature peptidoglycan.
FIG. 2.
FIG. 2.
Dendrogram of the FemABX protein family. Branch lengths are proportional to phylogenetic distances. Experimentally confirmed family members are shown in boldface type. The number of sequenced FemA homologs of Staphylococcus spp. has become quite large, and they are shown in an enlarged inset. The GenBank database was searched with the BLAST program (http://www.ncbi.nlm.nih.gov/BLAST/) (3) by using S. aureus FmhB as the query sequence. In the case of Streptococcus equi and Streptococcus pyogenes, three FemABX homologs were found, two of which are related to FibA/MurM of S. pneumoniae and one of which is related to FibB/MurN of S. pneumoniae. Unfinished microbial genomes were searched by using the tblastn program (http://www.ncbi.nlm.nih.gov/Microb_blast/unfinishedgenome.html). Preliminary sequence data from unfinished genomes were obtained from The Institute for Genomic Research website at http://www.tigr.org and from the Sanger Center at http://www.sanger.ac.uk. In the case of MurM, where multiple, more than 90% identical alleles are available, one representative sequence (that of strain R36A) was chosen. Protein sequences were aligned by using the ClustalW program (102), and the dendrogram was constructed by using the TreeView program (75).
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References

    1. Alborn, W. E. J., J. Hoskins, S. Unal, J. E. Flokowitsch, C. A. Hayes, J. E. Dotzlaf, W. K. Yeh, and P. L. Skatrud. 1996. Cloning and characterization of femA and femB from Staphylococcus epidermidis. Gene 180:177-181. - PubMed
    1. al-Obeid, S., D. Billot-Klein, J. van Heijenoort, E. Collatz, and L. Gutmann. 1992. Replacement of the essential penicillin-binding protein 5 by high-molecular mass PBPs may explain vancomycin-beta-lactam synergy in low-level vancomycin-resistant Enterococcus faecium D366. FEMS Microbiol. Lett. 70:79-84. - PubMed
    1. Altschul, S. F., T. L. Madden, A. A. Schäffer, J. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:3389-3402. - PMC - PubMed
    1. Baba, T., F. Takeuchi, M. Kuroda, H. Yuzawa, K. Aoki, A. Oguchi, Y. Nagai, N. Iwama, K. Asano, T. Naimi, H. Kuroda, L. Cui, K. Yamamoto, and K. Hiramatsu. 2002. Genome and virulence determinants of high virulence community-acquired MRSA. Lancet 359:1819-1827. - PubMed
    1. Barber, M. 1961. Methicillin-resistant staphylococci. J. Clin. Pathol. 14:385-393. - PMC - PubMed

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