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. 2003 Mar;47(3):1140-2.
doi: 10.1128/AAC.47.3.1140-1142.2003.

Postantibiotic effects of garenoxacin (BMS-284756) against 12 gram-positive or -negative organisms

G A Pankuch  1 , M R Jacobs, P C Appelbaum
Affiliations

Postantibiotic effects of garenoxacin (BMS-284756) against 12 gram-positive or -negative organisms

G A Pankuch et al. Antimicrob Agents Chemother. 2003 Mar.

Abstract

Conventional in vitro methods were used to determine the postantibiotic effects (PAEs), sub-MIC effects (SMEs), and postantibiotic sub-MIC effects (PA-SMEs) of garenoxacin for a range of organisms. The mean PAEs of garenoxacin for pneumococci, staphylococci, and enterococci were 0.3 to 2.2 h. For Escherichia coli and Pseudomonas aeruginosa, the PAEs were 0.9 to 1.6 h. The mean PA-SMEs (0.4 times the MIC) for pneumococci, staphylococci, and enterococci were 3.0 to >10 h, 1.8 to >10.7 h, and 5.8 h, respectively, while those for E. coli and P. aeruginosa were 7.6 and 4.4 h, respectively.

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References

    1. Bassetti, M., L. M. Dembry, P. A. Farrel, D. A. Callan, and V. T. Andriole. 2002. Antimicrobial activities of BMS-284756 compared with those of fluoroquinolones and β-lactams against gram-positive clinical isolates. Antimicrob. Agents Chemother. 46:234-238. - PMC - PubMed
    1. Cars, O., and I. Odenholt-Tornqvist. 1993. The post-antibiotic sub-MIC effect in vitro and in vivo. J. Antimicrob. Chemother. 31:159-166. - PubMed
    1. Craig, W. 1993. Pharmacodynamics of antimicrobial agents as a basis for determining dosage regimens. Eur. J. Clin. Microbiol. Infect. Dis. 12(Suppl. 1):6-8. - PubMed
    1. Craig, W. A., and S. Gudmundsson. 1996. Postantibiotic effect, p. 296-329. In V. Lorian (ed.), Antibiotics in laboratory medicine. The Williams and Wilkins Co., Baltimore, Md.
    1. Fix, A. M., M. A. Pfaller, D. J. Biedenbach, M. L. Beach, and R. N. Jones. 2001. Comparative antimicrobial spectrum of BMS284756 (T-3811, a desfluoroquinolone) tested against 656 Enterobacteriaceae, including preliminary in vitro susceptibility test comparisons and development. Diagn. Microbiol. Infect. Dis. 18:141-145. - PubMed

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