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Comparative Study
. 2003 Mar;47(3):1148-50.
doi: 10.1128/AAC.47.3.1148-1150.2003.

Antipneumococcal and antistaphylococcal activities of ranbezolid (RBX 7644), a new oxazolidinone, compared to those of other agents

Dianne B Hoellman  1 , Gengrong Lin, Lois M Ednie, Ashok Rattan, Michael R Jacobs, Peter C Appelbaum
Affiliations
Comparative Study

Antipneumococcal and antistaphylococcal activities of ranbezolid (RBX 7644), a new oxazolidinone, compared to those of other agents

Dianne B Hoellman et al. Antimicrob Agents Chemother. 2003 Mar.

Abstract

For 260 pneumococcal and 266 staphylococcal strains, ranbezolid MICs ranged from < or =0.06 to 4 micro g/ml. The MICs for pneumococci were similar irrespective of the strains' beta-lactam, macrolide, or quinolone susceptibilities, and ranbezolid MICs for coagulase-negative staphylococci were lower than those for Staphylococcus aureus. Ranbezolid was bacteriostatic against pneumococci. Ranbezolid MICs were similar to or lower than those of linezolid. Vancomycin and quinupristin-dalfopristin were also very active.

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