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. 2003 Mar;47(3):1165-8.
doi: 10.1128/AAC.47.3.1165-1168.2003.

Imipenem resistance in Salmonella enterica serovar Wien related to porin loss and CMY-4 beta-lactamase production

L Armand-Lefèvre  1 , V Leflon-Guibout, J Bredin, F Barguellil, A Amor, J M Pagès, M-H Nicolas-Chanoine
Affiliations

Imipenem resistance in Salmonella enterica serovar Wien related to porin loss and CMY-4 beta-lactamase production

L Armand-Lefèvre et al. Antimicrob Agents Chemother. 2003 Mar.

Abstract

Two multidrug-resistant Salmonella enterica serovar Wien strains (SW468 and SW1107) were isolated in 2001 in Tunis. Both strains produced the beta-lactamases TEM-1, SHV-2a, and CMY-4, whereas strain SW1107 also produced the beta-lactamase CTX-M-3. The imipenem-resistant strain (SW468) was totally devoid of the OmpF-immunorelated porin. Imipenem resistance was shown as being related to porin loss and CMY-4 beta-lactamase production.

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Figures

FIG. 1.
FIG. 1.
Immunodetection of outer membrane proteins. Labeling of membrane proteins of OmpF+ E. coli (lane 1), OmpF− E. coli (lane 2), and serovar Wien strains SW186 (lane 3), SW468 (lane 4), and SW1107 (lane 5) with anti-OmpF porin monomer antibodies (A), anti-loop3 antibodies (B), and anti-OmpA antibodies (C).
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