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. 2003 Mar 6;5(5):653-5.
doi: 10.1021/ol0272996.

Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols

Kazuhiko Takai  1 , Shuji Sakamoto, Takahiko Isshiki
Affiliations

Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols

Kazuhiko Takai et al. Org Lett. .

Abstract

Treatment of a mixture of a terminal alkyne and an aldehyde with CrCl(2) and a catalytic amount of NiCl(2) and triphenylphosphine in the presence of water in DMF at 25 degrees C gives a 1,2-disubstituted allylic alcohol regioselectively.

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