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. 2003 Mar 6;5(5):673-6.
doi: 10.1021/ol027437r.

Simplakidine A, a unique pyridinium alkaloid from the Caribbean sponge plakortis simplex

Claudio Campagnuolo  1 , Caterina Fattorusso, Ernesto Fattorusso, Angela Ianaro, Barbara Pisano, Orazio Taglialatela-Scafati
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Simplakidine A, a unique pyridinium alkaloid from the Caribbean sponge plakortis simplex

Claudio Campagnuolo et al. Org Lett. .

Abstract

Simplakidine A, a unique 4-alkyl-substituted pyridiunium alkaloid, has been isolated from the Caribbean sponge Plakortis simplex. The stereostructure of simplakidine A has been determined using MS and NMR data, molecular mechanics, and an extension of the J-based configuration analysis. Data about the growth-inhibition activity of simplakidine A are reported.

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