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Comment
. 2003 Mar 4;100(5):2177-9.
doi: 10.1073/pnas.0630492100. Epub 2003 Feb 26.

The hemodynamic inverse problem: making inferences about neural activity from measured MRI signals

Randy L Buckner  1
Affiliations
Comment

The hemodynamic inverse problem: making inferences about neural activity from measured MRI signals

Randy L Buckner. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
A schematic illustrates the linear transform model that specifies the relation between averaged neural activity and the temporally prolonged hemodynamic response measured by fMRI. Many properties of the relation between the two are still being explored, such as whether the MRI signal reflects averaged neural spiking or synaptic events (e.g., refs. , , and 28). The hemodynamic inverse problem concerns inferences in the opposite direction, exploring whether the measured hemodynamic response can be used to estimate underlying neural events. In the paper by Bellgowan et al. in a recent issue of PNAS (8), a model fit to the data was used to estimate the onset and width of the hemodynamic response and to make inferences about the timing and duration of underlying neural activity.
See this image and copyright information in PMC

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References

    1. Robinson D L, Rugg M D. Biol Psychol. 1988;26:111–116. - PubMed
    1. Raichle M E. In: Handbook of Physiology, The Nervous System. Mountcastle V B, Plum F, editors. Vol. 5. New York: Oxford Univ. Press; 1987. pp. 643–674.
    1. Kwong K K, Belliveau J W, Chesler D A, Goldberg I E, Weisskoff R M, Poncelet B P, Kennedy D N, Hoppel B E, Cohen M S, Turner R, et al. Proc Natl Acad Sci USA. 1992;89:5675–5679. - PMC - PubMed
    1. Ogawa S, Lee T M, Kay A R, Tank D W. Proc Natl Acad Sci USA. 1992;89:9868–9872. - PMC - PubMed
    1. Raichle M E. Proc Natl Acad Sci USA. 1998;95:765–772. - PMC - PubMed