Review
doi: 10.1046/j.1365-201X.2003.01085.x.
A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat
Affiliations
- PMID: 12609005
- DOI: 10.1046/j.1365-201X.2003.01085.x
Item in Clipboard
Review
A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat
Acta Physiol Scand.
2003 Mar.
Abstract
Aim: This manuscript briefly reviews evidence and potential implications of a leptin-sympathetic-leptin feedback loop.
Results: Leptin increases sympathetic nerve activity to brown adipose tissue, kidney and other tissues. This action has implications for regulation of arterial pressure. In turn, there is evidence that sympathoadrenal stimulation inhibits leptin mRNA expression and secretion from white adipose tissue through beta adrenergic mechanisms.
Conclusion: This sympathetic modulation of leptin expression has potential implications for regulation of body fat.
Similar articles
-
Leptin--a critical body weight signal and a "master" hormone?Sci STKE. 2003 Feb 11;2003(169):PE7. doi: 10.1126/stke.2003.169.pe7. Sci STKE. 2003. PMID: 12582201 Review.
-
Interaction between leptin and sympathetic nervous system in hypertension.Curr Hypertens Rep. 2000 Jun;2(3):311-8. doi: 10.1007/s11906-000-0015-1. Curr Hypertens Rep. 2000. PMID: 10981165 Review.
-
The role of the sympathetic nervous system in the regulation of leptin synthesis in C57BL/6 mice.FEBS Lett. 1999 Feb 12;444(2-3):149-54. doi: 10.1016/s0014-5793(99)00049-6. FEBS Lett. 1999. PMID: 10050748
-
The sympathetic nervous system in white adipose tissue regulation.Proc Nutr Soc. 2001 Aug;60(3):357-64. doi: 10.1079/pns2001101. Proc Nutr Soc. 2001. PMID: 11681810 Review.
-
Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor.Hypertension. 2011 Mar;57(3):627-32. doi: 10.1161/HYPERTENSIONAHA.110.166538. Epub 2011 Jan 24. Hypertension. 2011. PMID: 21263121 Free PMC article.
Cited by
-
Devices for the treatment of obesity: will understanding the physiology of satiety unravel new targets for intervention?J Diabetes Sci Technol. 2008 May;2(3):501-8. doi: 10.1177/193229680800200323. J Diabetes Sci Technol. 2008. PMID: 19885218 Free PMC article.
-
Beneficial Effects of an Aged Black Garlic Extract in the Metabolic and Vascular Alterations Induced by a High Fat/Sucrose Diet in Male Rats.Nutrients. 2019 Jan 12;11(1):153. doi: 10.3390/nu11010153. Nutrients. 2019. PMID: 30642033 Free PMC article.
-
Vitamin D Levels and Cardiometabolic Markers in Indigenous Argentinean Children Living at Different Altitudes.Glob Pediatr Health. 2019 Jan 8;6:2333794X18821942. doi: 10.1177/2333794X18821942. eCollection 2019. Glob Pediatr Health. 2019. PMID: 30671496 Free PMC article.
-
Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation.Diabetes. 2008 Sep;57(9):2304-10. doi: 10.2337/db07-1658. Epub 2008 Jun 10. Diabetes. 2008. PMID: 18544708 Free PMC article.
-
Developmental origins of obesity: programming of food intake or physical activity?Adv Exp Med Biol. 2009;646:83-93. doi: 10.1007/978-1-4020-9173-5_9. Adv Exp Med Biol. 2009. PMID: 19536666 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous
