Adjunctive clinical trials in epilepsy: is a placebo arm necessary?

Editorial

Ahmad Beydoun et al. Epilepsy Behav. 2003 Feb.

. 2003 Feb;4(1):4-5.

doi: 10.1016/s1525-5050(02)00682-0.

No abstract available

Comment in

Placebo effect in antiepileptic drug trials.
Burneo JG, Montori VM, Faught E. Burneo JG, et al. Epilepsy Behav. 2003 Jun;4(3):371. doi: 10.1016/s1525-5050(03)00112-4. Epilepsy Behav. 2003. PMID: 12791346 No abstract available.

Placebo effect in antiepileptic drug trials.
Burneo JG, Montori VM, Faught E. Burneo JG, et al. Epilepsy Behav. 2003 Jun;4(3):371. doi: 10.1016/s1525-5050(03)00112-4. Epilepsy Behav. 2003. PMID: 12791346 No abstract available.
The enigma of placebo effects in drug-refractory epilepsies.
Krämer G. Krämer G. Epilepsia. 2013 May;54 Suppl 2:13-5. doi: 10.1111/epi.12177. Epilepsia. 2013. PMID: 23646964 Review.
Epilepsy in infancy: answering the call.
Thio LL, Dodson WE. Thio LL, et al. Neurology. 2010 Mar 2;74(9):708-9. doi: 10.1212/WNL.0b013e3181d1cd65. Epub 2010 Jan 27. Neurology. 2010. PMID: 20107140 No abstract available.
Risk of sudden unexpected death in epilepsy in patients given adjunctive antiepileptic treatment for refractory seizures: a meta-analysis of placebo-controlled randomised trials.
Ryvlin P, Cucherat M, Rheims S. Ryvlin P, et al. Lancet Neurol. 2011 Nov;10(11):961-8. doi: 10.1016/S1474-4422(11)70193-4. Epub 2011 Sep 19. Lancet Neurol. 2011. PMID: 21937278
Meta-analysis of randomized trials on first line and adjunctive levetiracetam.
Lo BW, Kyu HH, Jichici D, Upton AM, Akl EA, Meade MO. Lo BW, et al. Can J Neurol Sci. 2011 May;38(3):475-86. doi: 10.1017/s0317167100011902. Can J Neurol Sci. 2011. PMID: 21515509 Review.