Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2003 Mar;56(3):233-6.
doi: 10.1136/jcp.56.3.233.

Soft tissue, pelvic, and urinary bladder leiomyosarcoma as second neoplasm following hereditary retinoblastoma

L Venkatraman  1 , J R Goepel, K Steele, S P Dobbs, R W Lyness, W G McCluggage
Affiliations
Case Reports

Soft tissue, pelvic, and urinary bladder leiomyosarcoma as second neoplasm following hereditary retinoblastoma

L Venkatraman et al. J Clin Pathol. 2003 Mar.

Abstract

This report describes two patients who developed leiomyosarcomas, one involving the subcutaneous tissue of the thigh and the pelvic soft tissues and the other the urinary bladder, following hereditary retinoblastoma 36 and 38 years earlier, respectively. There is an increased risk of the development of sarcoma, most commonly osteosarcoma, as a second malignancy following hereditary retinoblastoma. Leiomyosarcoma developing as a second malignancy has rarely been reported and most have occurred in the field of previous radiotherapy. The literature on leiomyosarcoma occurring as a second neoplasm following retinoblastoma is reviewed.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Area of moderate nuclear pleomorphism in thigh leiomyosarcoma (case 1).
Figure 2
Figure 2
Area of pronounced nuclear pleomorphism in pelvic leiomyosarcoma (case 1).
Figure 3
Figure 3
Foci of coagulative tumour cell necrosis in pelvic leiomyosarcoma (case 1).
Figure 4
Figure 4
MIB1 staining showing a proliferative index of 35–40% (case 1).
Figure 5
Figure 5
Urinary bladder leiomyosarcoma exhibiting moderate nuclear pleomorphism (case 2).
Figure 6
Figure 6
Urinary bladder leiomyosarcoma exhibiting strong nuclear staining for p53 (case 2).
See this image and copyright information in PMC

References

    1. Draper GJ, Sanders BM, Kingston JE. Second primary neoplasms in patients with retinoblastoma. Br J Cancer 1986;53:661–71. - PMC - PubMed
    1. Moll AC, Imhof SM, Schouten-Van Meeteren AY, et al. Second primary tumours in hereditary retinoblastoma: a register based study, 1945–1997: is there an age effect on radiation-related risk? Ophthalmology 2001;108:1109–14. - PubMed
    1. Abramson DH, Ellsworth RM, Kitchen FD, et al. Second non-ocular tumours in retinoblastoma survivors. Are they radiation-induced? Ophthalmology 1984;91:1351–5. - PubMed
    1. Martin-Hirsch DP, Habashi S, Benbow EW, et al. Post-irradiation leiomyosarcoma of the maxilla. J Laryngol Otol 1991;105:1068–71. - PubMed
    1. Guse TR, Weiss LD. Leiomyosarcoma of the femur in a patient with a history of retinoblastoma. J Bone Joint Surg 1994;6:904–6. - PubMed

Publication types